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Important Safety Information
NAD+ injections
Read this before starting treatment. It is a summary of the most important safety information, not a complete list.
Last updated 8 August 2026
Off-label use notice
NAD+ (nicotinamide adenine dinucleotide) is not FDA-approved for the treatment, cure or prevention of any disease. Its use for energy, cognition, healthy aging or general wellness is off-label.
Off-label prescribing is legal and common, but it means the FDA has not evaluated the evidence for this use. Clinical evidence for injected NAD+ in healthy adults is limited. No outcome is promised or guaranteed.
About compounded medication. The medication described here is prepared for an individual patient by a state-licensed compounding pharmacy. It is not FDA-approved for safety and effectiveness, and the FDA does not review compounded preparations for quality, strength or purity before they are dispensed. The safety information below is drawn from the FDA-approved labelling for the same active ingredient.
What this is
NAD+ is a coenzyme found in every cell in the body, where it takes part in energy metabolism and cellular repair. DonoMed prescribes it as a subcutaneous injection on a provider-guided protocol. It is prescribed only after a licensed provider reviews your health history and determines it is appropriate for you.
Tell your provider before starting if you
- Are pregnant, trying to become pregnant, or breastfeeding.
- Have kidney or liver disease.
- Have a heart condition, or have had chest pain or arrhythmia.
- Have low blood pressure, or take medication for blood pressure.
- Have had an allergic reaction to an injected preparation before.
- Take any other medication or supplement.
Common side effects
Injection-site pain, redness, swelling or bruising. Flushing, warmth, nausea, headache, light-headedness, chest tightness, abdominal cramping and a general "rushing" sensation are common when the injection is given too quickly — injecting slowly usually prevents them. Fatigue and muscle cramps are also reported.
Serious side effects — stop and seek care
- Serious allergic reaction. Swelling of the face, lips, tongue or throat, difficulty breathing, or widespread rash. Call 911.
- Chest pain, a racing or irregular heartbeat, or fainting.
- Signs of injection-site infection. Spreading redness, warmth, pus, or fever.
Storage and handling
Store as instructed on your label, protected from light, and out of reach of children. Do not use after the beyond-use date. Never share your medication, needles or syringes. Dispose of used needles in an approved sharps container.
This summary is not complete
The information above is a summary and does not list every possible risk, interaction or side effect. Discuss your full health history and all medications and supplements you take with your provider before starting treatment.
Reporting a problem
Tell your provider about any side effect. You can also report side effects directly to the FDA at fda.gov/medwatch or by calling 1-800-FDA-1088. If you think you are having a medical emergency, call 911.