This is a summary, not a substitute for the full guidance your provider and pharmacy will give you. Read all materials that come with your medication and ask your provider about anything you don't understand.
⚠ Serious risks & who should not use GLP-1s
Thyroid tumors: In animal studies, GLP-1 medications caused thyroid C-cell tumors. It is not known whether they cause these tumors in people. Do not use if you or a family member has had medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your provider about any lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.
Do not use if you are pregnant, planning to become pregnant, or breastfeeding, or if you have had a serious allergic reaction to semaglutide, tirzepatide, or any ingredient in these medications.
Tell your provider if you have or have had pancreatitis, gallbladder problems, kidney disease, severe stomach or digestion problems, diabetic retinopathy, or a history of depression or suicidal thoughts.
Possible serious side effects include inflammation of the pancreas (pancreatitis), gallbladder problems, low blood sugar (especially if used with insulin or other diabetes medicines), kidney injury from dehydration, serious allergic reactions, and changes in vision. Seek care right away for severe abdominal pain, persistent vomiting, or signs of an allergic reaction.
Common side effects are mostly digestive — nausea, vomiting, diarrhea, constipation, and abdominal discomfort — and often lessen over time.
About compounded medications: Compounded semaglutide and tirzepatide are prepared by state-licensed compounding pharmacies and are not FDA-approved. They are prescribed only after evaluation by a licensed provider who determines the treatment is appropriate for you.